Endotoxin preconditioning reprograms S1 tubules and macrophages to protect the kidney

T Hato, A Zollman, Z Plotkin, TM El-Achkar… - Journal of the …, 2018 - journals.lww.com
Preconditioning with a low dose of endotoxin confers unparalleled protection against
otherwise lethal models of sepsis. The mechanisms of preconditioning have been
investigated extensively in isolated immune cells such as macrophages. However, the role
of tissue in mediating the protective response generated by preconditioning remains
unknown. Here, using the kidney as a model organ, we investigated cell type–specific
responses to preconditioning. Compared with preadministration of vehicle, endotoxin …