Promoter hypermethylation of TERT is associated with hepatocellular carcinoma in the Han Chinese population

H Zhang, X Weng, J Ye, L He, D Zhou, Y Liu - Clinics and research in …, 2015 - Elsevier
Background Upstream of the transcription start site (UTSS), hypermethylation of the
telomerase reverse transcriptase (TERT) gene has been shown to be associated with
tumour progression and a poor prognosis in paediatric brain tumours (Castelo-Branco
2013). It has been inferred that the UTSS region of TERT is a potentially accessible
biomarker for various cancers. In this study, we aimed to explore the role of TERT in
hepatocellular carcinoma (HCC) and to investigate whether the UTSS region of the TERT …