[HTML][HTML] Complement dependence of murine costimulatory blockade-resistant cellular cardiac allograft rejection
N Chun, RL Fairchild, Y Li, J Liu, M Zhang… - American Journal of …, 2017 - Elsevier
Building on studies showing that ischemia–reperfusion-(I/R)-injury is complement
dependent, we tested links among complement activation, transplantation-associated I/R
injury, and murine cardiac allograft rejection. We transplanted BALB/c hearts subjected to 8-
h cold ischemic storage (CIS) into cytotoxic T-lymphocyte associated protein 4 (CTLA4) Ig-
treated wild-type (WT) or c3−/− B6 recipients. Whereas allografts subjected to 8-h CIS
rejected in WT recipients with a median survival time (MST) of 37 days, identically treated …
dependent, we tested links among complement activation, transplantation-associated I/R
injury, and murine cardiac allograft rejection. We transplanted BALB/c hearts subjected to 8-
h cold ischemic storage (CIS) into cytotoxic T-lymphocyte associated protein 4 (CTLA4) Ig-
treated wild-type (WT) or c3−/− B6 recipients. Whereas allografts subjected to 8-h CIS
rejected in WT recipients with a median survival time (MST) of 37 days, identically treated …
