A central role for JNK in obesity and insulin resistance

J Hirosumi, G Tuncman, L Chang, CZ Görgün… - Nature, 2002 - nature.com
J Hirosumi, G Tuncman, L Chang, CZ Görgün, KT Uysal, K Maeda, M Karin, GS Hotamisligil
Nature, 2002nature.com
Obesity is closely associated with insulin resistance and establishes the leading risk factor
for type 2 diabetes mellitus, yet the molecular mechanisms of this association are poorly
understood. The c-Jun amino-terminal kinases (JNKs) can interfere with insulin action in
cultured cells and are activated by inflammatory cytokines and free fatty acids, molecules
that have been implicated in the development of type 2 diabetes,. Here we show that JNK
activity is abnormally elevated in obesity. Furthermore, an absence of JNK1 results in …
Abstract
Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanisms of this association are poorly understood. The c-Jun amino-terminal kinases (JNKs) can interfere with insulin action in cultured cells and are activated by inflammatory cytokines and free fatty acids, molecules that have been implicated in the development of type 2 diabetes,. Here we show that JNK activity is abnormally elevated in obesity. Furthermore, an absence of JNK1 results in decreased adiposity, significantly improved insulin sensitivity and enhanced insulin receptor signalling capacity in two different models of mouse obesity. Thus, JNK is a crucial mediator of obesity and insulin resistance and a potential target for therapeutics.
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