MYC and aggressive B-cell lymphomas

GW Slack, RD Gascoyne - Advances in anatomic pathology, 2011 - journals.lww.com
Rearrangement of the proto-oncogene MYC leads to MYC protein deregulation and is an
important driver of oncogenic transformation. MYC rearrangement is a recurring genetic
abnormality in several aggressive B-cell lymphomas including: Burkitt lymphoma, diffuse
large B-cell lymphoma; B-cell lymphoma, unclassifiable with features intermediate between
diffuse large B-cell lymphoma and Burkitt lymphoma; rare de novo acute lymphoblastic
lymphoma/leukemia, transformed follicular lymphoma, and plasmablastic lymphoma …