Hypoxia and antitumor CD8+ T cells: An incompatible alliance?
R Vuillefroy de Silly, PY Dietrich, PR Walker - Oncoimmunology, 2016 - Taylor & Francis
R Vuillefroy de Silly, PY Dietrich, PR Walker
Oncoimmunology, 2016•Taylor & FrancisABSTRACT T Lymphocytes face pathologically low O2 tensions within the tumor bed at
which they will have to function in order to impact on the malignancy. Recent studies
highlighting the importance of O2 and hypoxia-inducible factors for CD8+ T-cell function and
fate must now be integrated into tumor immunology concepts if immunotherapies are to
progress. Here, we discuss, reinterpret, and reconcile the many apparent contradictions in
these data and we propose that O2 is a master regulator of the CD8+ T-cell response …
which they will have to function in order to impact on the malignancy. Recent studies
highlighting the importance of O2 and hypoxia-inducible factors for CD8+ T-cell function and
fate must now be integrated into tumor immunology concepts if immunotherapies are to
progress. Here, we discuss, reinterpret, and reconcile the many apparent contradictions in
these data and we propose that O2 is a master regulator of the CD8+ T-cell response …
Abstract
T Lymphocytes face pathologically low O2 tensions within the tumor bed at which they will have to function in order to impact on the malignancy. Recent studies highlighting the importance of O2 and hypoxia-inducible factors for CD8+ T-cell function and fate must now be integrated into tumor immunology concepts if immunotherapies are to progress. Here, we discuss, reinterpret, and reconcile the many apparent contradictions in these data and we propose that O2 is a master regulator of the CD8+ T-cell response. Certain T cell functions are enhanced, others suppressed, but on balance, hypoxia is globally detrimental to the antitumor response.
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