[HTML][HTML] TMTC1 and TMTC2 are novel endoplasmic reticulum tetratricopeptide repeat-containing adapter proteins involved in calcium homeostasis
JC Sunryd, B Cheon, JB Graham, KM Giorda… - Journal of Biological …, 2014 - ASBMB
The endoplasmic reticulum (ER) is organized in part by adapter proteins that nucleate the
formation of large protein complexes. Tetratricopeptide repeats (TPR) are well studied
protein structural motifs that support intermolecular protein-protein interactions. TMTC1 and
TMTC2 were identified by an in silico search as TPR-containing proteins possessing N-
terminal ER targeting signal sequences and multiple hydrophobic segments, suggestive of
polytopic membrane proteins that are targeted to the secretory pathway. A variety of cell …
formation of large protein complexes. Tetratricopeptide repeats (TPR) are well studied
protein structural motifs that support intermolecular protein-protein interactions. TMTC1 and
TMTC2 were identified by an in silico search as TPR-containing proteins possessing N-
terminal ER targeting signal sequences and multiple hydrophobic segments, suggestive of
polytopic membrane proteins that are targeted to the secretory pathway. A variety of cell …