Age-related hearing loss and the ahl locus in mice
EM Keithley, C Canto, QY Zheng, N Fischel-Ghodsian… - Hearing research, 2004 - Elsevier
C57BL/6 (B6) mice experience hearing loss and cochlear degeneration beginning about
mid-life, whereas CAST/Ei (CAST) mice retain normal hearing until old age. A locus
contributing to the hearing loss of B6 mice, named age-related hearing loss (ahl), was
mapped to Chromosome 10. A homozygous, congenic strain of mice (B6. CAST-+ ahl),
generated by crossing B6 (ahl/ahl) and CAST (+ ahl/+ ahl) mice has the same genomic
material as the B6 mice except in the region of the ahl locus, which is derived from CAST. In …
mid-life, whereas CAST/Ei (CAST) mice retain normal hearing until old age. A locus
contributing to the hearing loss of B6 mice, named age-related hearing loss (ahl), was
mapped to Chromosome 10. A homozygous, congenic strain of mice (B6. CAST-+ ahl),
generated by crossing B6 (ahl/ahl) and CAST (+ ahl/+ ahl) mice has the same genomic
material as the B6 mice except in the region of the ahl locus, which is derived from CAST. In …