[HTML][HTML] Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets …
ER Pereira, K Frudd, W Awad… - Journal of Biological …, 2014 - ASBMB
Cells respond to suboptimal microenvironments by activating stress signaling pathways, like
the unfolded protein response and hypoxia-induced transcription factors HIF-1/2, to restore
homeostasis. Both cytoprotective pathways have been well studied in isolation at the
biochemical and molecular levels. Mounting evidence reveals that they can be activated
simultaneously in tumor cells and, likely, in other tissues experiencing inadequate
microenvironments and that they share some transcriptional targets, like the proangiogenic …
the unfolded protein response and hypoxia-induced transcription factors HIF-1/2, to restore
homeostasis. Both cytoprotective pathways have been well studied in isolation at the
biochemical and molecular levels. Mounting evidence reveals that they can be activated
simultaneously in tumor cells and, likely, in other tissues experiencing inadequate
microenvironments and that they share some transcriptional targets, like the proangiogenic …