[HTML][HTML] Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria
H Sugimoto, Y Hamano, D Charytan… - Journal of Biological …, 2003 - ASBMB
There are about 2.5 million glomeruli in the kidneys each consisting of a barrel of glomerular
basement membrane surrounded by glomerular endothelial cells on the inside and
glomerular epithelial cells with established foot processes (podocytes) on the outside.
Defects in this filtration apparatus lead to glomerular vascular leak or proteinuria. The role of
vascular endothelial growth factor (VEGF) in the regulation of glomerular vascular
permeability is still unclear. Recent studies indicate that patients receiving anti-VEGF …
basement membrane surrounded by glomerular endothelial cells on the inside and
glomerular epithelial cells with established foot processes (podocytes) on the outside.
Defects in this filtration apparatus lead to glomerular vascular leak or proteinuria. The role of
vascular endothelial growth factor (VEGF) in the regulation of glomerular vascular
permeability is still unclear. Recent studies indicate that patients receiving anti-VEGF …