[HTML][HTML] Effect of low birth weight on childhood asthma: a meta-analysis
XF Xu, YJ Li, YJ Sheng, JL Liu, LF Tang, ZM Chen - BMC pediatrics, 2014 - Springer
XF Xu, YJ Li, YJ Sheng, JL Liu, LF Tang, ZM Chen
BMC pediatrics, 2014•SpringerBackground Low birth weight is strongly correlated with an increased risk of adult diseases.
Additionally, low birth weight might be a risk factor for asthma later in life. Methods A
systematic literature search of the PubMed database from 1966 to November 2013 was
conducted. The criteria for inclusion of papers were as follows: case–control or cohort
studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95%
confidence intervals (CIs) were presented, or there were sufficient data for calculation; and …
Additionally, low birth weight might be a risk factor for asthma later in life. Methods A
systematic literature search of the PubMed database from 1966 to November 2013 was
conducted. The criteria for inclusion of papers were as follows: case–control or cohort
studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95%
confidence intervals (CIs) were presented, or there were sufficient data for calculation; and …
Background
Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.
Methods
A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case–control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.
Results
Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128–1.197) and 1.152 (random-effects model, 95% CI, 1.082–1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.
Conclusions
This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.
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