[HTML][HTML] The impact of sterile inflammation in acute liver injury
BL Woolbright, H Jaeschke - Journal of clinical and translational …, 2017 - ncbi.nlm.nih.gov
Journal of clinical and translational research, 2017•ncbi.nlm.nih.gov
Background: The liver has a number of functions in innate immunity. These functions
predispose the liver to innate immune-mediated liver injury when inflammation goes
unchecked. Significant progress has been made in the last 25 years on sterile inflammatory
liver injury in a number of models; however, a great deal of controversy and many questions
about the nature of sterile inflammation still exist. Aim: The goal of this article is to review
sterile inflammatory liver injury using both a basic approach to what constitutes the …
predispose the liver to innate immune-mediated liver injury when inflammation goes
unchecked. Significant progress has been made in the last 25 years on sterile inflammatory
liver injury in a number of models; however, a great deal of controversy and many questions
about the nature of sterile inflammation still exist. Aim: The goal of this article is to review
sterile inflammatory liver injury using both a basic approach to what constitutes the …
Abstract
Background: The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver injury in a number of models; however, a great deal of controversy and many questions about the nature of sterile inflammation still exist.
Aim: The goal of this article is to review sterile inflammatory liver injury using both a basic approach to what constitutes the inflammatory injury, and through examination of current models of liver injury and inflammation. This information will be tied to human patient conditions when appropriate.
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