Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin
R El Mezayen, M El Gazzar, MC Seeds, CE McCall… - Immunology letters, 2007 - Elsevier
Stressed cells undergoing necrosis release molecules that acts as endogenous danger
signals to alert and activate innate immune cells. Both HMGB1 and HSP70 are induced in
activated monocytes/macrophages and also are released from stressed or injured cells. We
investigated whether HMGB1 and HSP70 released from necrotic monocytes/macrophages,
can act as danger signals to mediate proinflammatory cytokine responses to bacterial
endotoxin or lipopolysaccharide (LPS). We show that cell lysate, obtained from necrotic cells …
signals to alert and activate innate immune cells. Both HMGB1 and HSP70 are induced in
activated monocytes/macrophages and also are released from stressed or injured cells. We
investigated whether HMGB1 and HSP70 released from necrotic monocytes/macrophages,
can act as danger signals to mediate proinflammatory cytokine responses to bacterial
endotoxin or lipopolysaccharide (LPS). We show that cell lysate, obtained from necrotic cells …