Oxygen-and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro.
PB McCay, EK Lai, JL Poyer, CM DuBose… - Journal of Biological …, 1984 - ASBMB
Free radical reactions involved in the metabolism of carbon tetrachloride by rat liver have
been considered to be a cause of at least part of the injury resulting from exposure to this
halocarbon. In an earlier study employing electron spin resonance and spin-trapping
techniques, we demonstrated that trichloromethyl (13. CCl3) radicals are readily observed in
rat liver microsomes metabolizing 13CCl4, and that the same radical could be shown to form
in vivo in the liver of intact rats given a single dose of 13CCl4. This report describes the …
been considered to be a cause of at least part of the injury resulting from exposure to this
halocarbon. In an earlier study employing electron spin resonance and spin-trapping
techniques, we demonstrated that trichloromethyl (13. CCl3) radicals are readily observed in
rat liver microsomes metabolizing 13CCl4, and that the same radical could be shown to form
in vivo in the liver of intact rats given a single dose of 13CCl4. This report describes the …