Glutathione S-transferase gene polymorphisms in presbycusis
Otology & Neurotology, 2005•journals.lww.com
Results: Gene polymorphisms at GSTM1, GSTT1, and GSTP1 in subjects with presbycusis
were not significantly different than in the controls (p> 0.05). Also, the combinations of
different GSTM1, GSTT1, and GSTP1 genotypes were not an increased risk of presbycusis
(p> 0.05). Conclusion: We could not demonstrate any significant association between the
GSTM1, GSTT1, and GSTP1 polymorphism and age-related hearing loss in this population.
This may be because of our sample size, and further studies need to investigate the exact …
were not significantly different than in the controls (p> 0.05). Also, the combinations of
different GSTM1, GSTT1, and GSTP1 genotypes were not an increased risk of presbycusis
(p> 0.05). Conclusion: We could not demonstrate any significant association between the
GSTM1, GSTT1, and GSTP1 polymorphism and age-related hearing loss in this population.
This may be because of our sample size, and further studies need to investigate the exact …
Results:
Gene polymorphisms at GSTM1, GSTT1, and GSTP1 in subjects with presbycusis were not significantly different than in the controls (p> 0.05). Also, the combinations of different GSTM1, GSTT1, and GSTP1 genotypes were not an increased risk of presbycusis (p> 0.05).
Conclusion:
We could not demonstrate any significant association between the GSTM1, GSTT1, and GSTP1 polymorphism and age-related hearing loss in this population. This may be because of our sample size, and further studies need to investigate the exact role of GST gene polymorphisms in the etiopathogenesis of the presbycusis.
Lippincott Williams & Wilkins