Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study
MY Kim, JP Buyon, MM Guerra, S Rana… - American journal of …, 2016 - Elsevier
Background Over 20% of pregnancies in patients with systemic lupus erythematosus (SLE)
and/or antiphospholipid antibodies (APL) result in an adverse pregnancy outcome (APO)
related to abnormal placentation. The ability to identify, early in pregnancy, patients who are
destined for poor outcomes would significantly impact care of this high-risk population. In
nonautoimmune patients, circulating angiogenic factors are dysregulated in disorders of
placentation, such as preeclampsia (PE) and fetal growth restriction. Objective We sought to …
and/or antiphospholipid antibodies (APL) result in an adverse pregnancy outcome (APO)
related to abnormal placentation. The ability to identify, early in pregnancy, patients who are
destined for poor outcomes would significantly impact care of this high-risk population. In
nonautoimmune patients, circulating angiogenic factors are dysregulated in disorders of
placentation, such as preeclampsia (PE) and fetal growth restriction. Objective We sought to …