FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?

C Fischer, M Mazzone, B Jonckx, P Carmeliet - Nature Reviews Cancer, 2008 - nature.com
C Fischer, M Mazzone, B Jonckx, P Carmeliet
Nature Reviews Cancer, 2008nature.com
Less than 5 years ago, it was still not clear whether anti-angiogenic drugs would prove
successful in the clinic. After numerous patients with cancer or age-related macular
degeneration have been treated with these drugs, they have now become part of the
standard range of therapeutic tools. Despite this milestone, anti-angiogenic therapy still
faces a number of clinical hurdles, such as improving efficacy, avoiding escape and
resistance, and minimizing toxicity. Hopefully, other agents with complementary …
Abstract
Less than 5 years ago, it was still not clear whether anti-angiogenic drugs would prove successful in the clinic. After numerous patients with cancer or age-related macular degeneration have been treated with these drugs, they have now become part of the standard range of therapeutic tools. Despite this milestone, anti-angiogenic therapy still faces a number of clinical hurdles, such as improving efficacy, avoiding escape and resistance, and minimizing toxicity. Hopefully, other agents with complementary mechanisms, such as those that target placental growth factor, will offer novel opportunities for improved treatment.
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