Monocyte phenotypes: when local education counts

AA Quintar, CC Hedrick, K Ley - Journal of Experimental Medicine, 2015 - rupress.org
Journal of Experimental Medicine, 2015rupress.org
A focal sterile injury induces the recruitment of CCR2hi monocytes (red) to the liver, which
form a ring surrounding and" walling off" the necrotic lesion. After 48–72 hours, monocytes
start to gain CX3CR1 expression (orange) and undergo an IL-4/IL-10–mediated phenotypic
conversion into CCR2low CX3CR1hi CD11bhi MHCIIhi CD64hi F4/80-monocytes (green).
These cells infiltrate the necrotic tissue and induce collagen deposition leading to the
clearance of dead cells.
A focal sterile injury induces the recruitment of CCR2hi monocytes (red) to the liver, which form a ring surrounding and" walling off" the necrotic lesion. After 48–72 hours, monocytes start to gain CX3CR1 expression (orange) and undergo an IL-4/IL-10–mediated phenotypic conversion into CCR2low CX3CR1hi CD11bhi MHCIIhi CD64hi F4/80-monocytes (green). These cells infiltrate the necrotic tissue and induce collagen deposition leading to the clearance of dead cells.
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