Inhibition of neogenin dampens hepatic ischemia-reperfusion injury
M Schlegel, T Granja, S Kaiser, A Körner… - Critical Care …, 2014 - journals.lww.com
Objective: Liver ischemia and reperfusion injury is a common source of significant morbidity
and mortality following liver transplantation, hemorrhagic shock, or major hepatic surgery.
Based on studies showing a critical role for the neuronal guidance receptor neogenin
(Neo1) outside the nervous system in mediating tissue adaption during acute inflammation,
we hypothesized that Neo1 enhances hepatic ischemia and reperfusion injury. Design:
Animal study. Setting: University-based experimental laboratory. Subjects: Wid-type …
and mortality following liver transplantation, hemorrhagic shock, or major hepatic surgery.
Based on studies showing a critical role for the neuronal guidance receptor neogenin
(Neo1) outside the nervous system in mediating tissue adaption during acute inflammation,
we hypothesized that Neo1 enhances hepatic ischemia and reperfusion injury. Design:
Animal study. Setting: University-based experimental laboratory. Subjects: Wid-type …
