Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
D Hoeller, CM Hecker, I Dikic - Nature Reviews Cancer, 2006 - nature.com
D Hoeller, CM Hecker, I Dikic
Nature Reviews Cancer, 2006•nature.comUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many
cellular functions, such as cell proliferation, apoptosis, the cell cycle and DNA repair. It is
becoming apparent that the deregulation of ubiquitin pathways results in the development of
human diseases, including many types of tumours. Here we summarize the common
principles and specific features of ubiquitin and Ubls in the regulation of cancer-relevant
pathways, and discuss new strategies to target ubiquitin signalling in drug discovery.
cellular functions, such as cell proliferation, apoptosis, the cell cycle and DNA repair. It is
becoming apparent that the deregulation of ubiquitin pathways results in the development of
human diseases, including many types of tumours. Here we summarize the common
principles and specific features of ubiquitin and Ubls in the regulation of cancer-relevant
pathways, and discuss new strategies to target ubiquitin signalling in drug discovery.
Abstract
Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, the cell cycle and DNA repair. It is becoming apparent that the deregulation of ubiquitin pathways results in the development of human diseases, including many types of tumours. Here we summarize the common principles and specific features of ubiquitin and Ubls in the regulation of cancer-relevant pathways, and discuss new strategies to target ubiquitin signalling in drug discovery.
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