[HTML][HTML] Regulatory T cells decrease invariant natural killer T cell-mediated pregnancy loss in mice
Pregnancy loss is the commonest complication of pregnancy. The causes of pregnancy loss
are poorly understood. It has been reported that stimulation of invariant natural killer T
(iNKT) cells using α-galactosylceramide (αGC) induces pregnancy loss in mice. Here we
investigated the mechanisms, especially the role of regulatory T (Treg) cells, in iNKT cell-
mediated pregnancy loss. We found that injection of αGC rapidly induced fetal resorption,
activated decidual iNKT cells, decreased the percentage of decidual Treg cells and their …
are poorly understood. It has been reported that stimulation of invariant natural killer T
(iNKT) cells using α-galactosylceramide (αGC) induces pregnancy loss in mice. Here we
investigated the mechanisms, especially the role of regulatory T (Treg) cells, in iNKT cell-
mediated pregnancy loss. We found that injection of αGC rapidly induced fetal resorption,
activated decidual iNKT cells, decreased the percentage of decidual Treg cells and their …