An epidemiologic study of contraception and preeclampsia

HS Klonoff-Cohen, DA Savitz, RC Cefalo, MF McCANN - Jama, 1989 - jamanetwork.com
The primary hypothesis of this study was that contraceptive methods that prevent exposure
to sperm and seminal fluid (condoms, diaphragms, spermicides, withdrawal) are associated
with an increased risk of developing preeclampsia during the subsequent pregnancy. A
case-control study was conducted comparing the contraceptive and reproductive histories of
110 primiparous women with preeclampsia with 115 pregnant women without preeclampsia,
aged 15 to 35 years, who gave birth at North Carolina Memorial Hospital, Chapel Hill …