Pregnancy constitutes a major challenge to the maternal immune system, as it requires
tolerance of paternal alloantigen. Maternal rejection of the fetus may develop when T
regulatory (Treg) cells fail to control the balance between tolerance and immunity.
Increasing evidence supports the role of IL-6 trans-signaling within T cells as a key pathway
for blockade of the development of adaptive Treg cells. The present study investigated
whether alteration of the components of the IL-6 trans-signaling might be a mechanism …