Paternal antigen-specific proliferating regulatory T cells are increased in uterine-draining lymph nodes just before implantation and in pregnant uterus just after …

T Shima, K Inada, A Nakashima, A Ushijima… - Journal of reproductive …, 2015 - Elsevier
Paternal antigen-specific regulatory T (PA-specific Treg) cells play an important role in feto-
maternal tolerance. To detect the PA-specific Tregs, female BALB/c mice were mated with
male DBA/2 mice. Mls Ia antigen on DBA/2 mice is recognized by the T-cell receptor Vβ6;
thus, CD4+ Foxp3+ Vβ6+ cells are recognized as PA-specific Treg cells. CD4+ CD25+ Vβ6+
cells effectively suppressed the allo-reactive proliferation of lymphocytes compared with that
of CD4+ CD25+ Vβ6− cells. Vβ6+ PA-specific Treg cells expressed CCR4 and CCR5 on …