The effect of one injection of Depo-Provera® on the human vaginal epithelium and cervical ectopy

CK Mauck, MM Callahan, J Baker, K Arbogast… - Contraception, 1999 - Elsevier
Two studies in rhesus monkeys have shown that progesterone implants, Depo-Provera®
and Norplant®, were associated with vaginal thinning. Progesterone implants have also
been associated with an increased risk of simian immunodeficiemcy virus (SIV) acquisition.
This study in 16 women was done to assess vaginal epithelial thickness and number of cell
layers from biopsies taken in the untreated follicular and luteal phases, and at 1 month and 3
months after administration of Depo-Provera. There was no significant change over time in …