Formation and functions of the corneocyte lipid envelope (CLE)
PM Elias, R Gruber, D Crumrine, G Menon… - … et Biophysica Acta (BBA …, 2014 - Elsevier
PM Elias, R Gruber, D Crumrine, G Menon, ML Williams, JS Wakefield, WM Holleran…
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2014•ElsevierCorneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently
bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review
here the structure, composition, and possible functions of this structure, with insights
provided by inherited and acquired disorders of lipid metabolism. This article is part of a
Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the
Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold …
bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review
here the structure, composition, and possible functions of this structure, with insights
provided by inherited and acquired disorders of lipid metabolism. This article is part of a
Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the
Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold …
Abstract
Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
Elsevier