Depomedroxyprogesterone-induced hypoestrogenism and changes in vaginal flora and epithelium
L Miller, DL Patton, A Meier, SS Thwin, TM Hooton… - Obstetrics & …, 2000 - Elsevier
Objective: To identify the effects of depomedroxyprogesterone acetate (DMPA) on vaginal
microbial flora and epithelium. Methods: Women who desired DMPA for contraception were
evaluated before and at 3 and 6 months after initiation of 150-mg DMPA injections every 3
months. At each visit, we assessed genital symptoms, vaginal signs, vaginal microflora, and
histopathology by vaginal biopsies. Results: Among 38 women observed for 6 months, there
was significant reduction in mean serum estradiol level (99.9±9.3 pg/mL to 26.6±1.6 pg/mL …
microbial flora and epithelium. Methods: Women who desired DMPA for contraception were
evaluated before and at 3 and 6 months after initiation of 150-mg DMPA injections every 3
months. At each visit, we assessed genital symptoms, vaginal signs, vaginal microflora, and
histopathology by vaginal biopsies. Results: Among 38 women observed for 6 months, there
was significant reduction in mean serum estradiol level (99.9±9.3 pg/mL to 26.6±1.6 pg/mL …