Correlations between sequence evolution and structural dynamics are of utmost importance in understanding the molecular mechanisms of function and their evolution. We have integrated Evol , a new package for fast and efficient comparative analysis of evolutionary patterns and conformational dynamics, into ProDy , a computational toolbox designed for inferring pro tein dyn amics from experimental and theoretical data. Using information-theoretic approaches, Evol coanalyzes conservation and coevolution profiles extracted from multiple sequence alignments of protein families with their inferred dynamics.

Availability and implementation:  ProDy and Evol are open-source and freely available under MIT License fromhttp://prody.csb.pitt.edu/.

Contact:  bahar@pitt.edu