Publisher Summary This chapter focuses on the abnormal major histocompatibility complex
(MHC) expression detected in human tumors as well as on the biological role that these
alterations may have in tumor development. The potential therapeutic implications of these
discoveries are discussed in the chapter. MHC constitutes a set of genes that synthesize
products specializing in the processing and presentation of endogenous and exogenous
antigens to the immune system. Four major categories of genes are involved in this …