[HTML][HTML] Ah receptor represses acute-phase response gene expression without binding to its cognate response element
RD Patel, IA Murray, CA Flaveny, A Kusnadi… - Laboratory …, 2009 - Elsevier
Repression of the nuclear factor-κB (NF-κB) pathway has been extensively researched
because of its pivotal role in inflammation. We investigated the potential of the aryl
hydrocarbon receptor (AHR) to suppress NF-κB regulated-gene expression, especially
acute-phase genes, such as serum amyloid A (Saa). Using AHR mutants, it was determined
that nuclear translocation and heterodimerization with AHR-nuclear translocator are
essential, but DNA binding is not involved in AHR-mediated Saa repression. A number of …
because of its pivotal role in inflammation. We investigated the potential of the aryl
hydrocarbon receptor (AHR) to suppress NF-κB regulated-gene expression, especially
acute-phase genes, such as serum amyloid A (Saa). Using AHR mutants, it was determined
that nuclear translocation and heterodimerization with AHR-nuclear translocator are
essential, but DNA binding is not involved in AHR-mediated Saa repression. A number of …