[HTML][HTML] Aryl hydrocarbon receptor modulation of tumor necrosis factor-α-induced apoptosis and lysosomal disruption in a hepatoma model that is caspase-8 …

JA Caruso, PA Mathieu, A Joiakim, H Zhang… - Journal of biological …, 2006 - ASBMB
Recent studies suggest that the aryl hydrocarbon receptor (AhR) modulates susceptibilities
to some pro-apoptotic agents. AhR-containing murine hepatoma 1c1c7 cultures underwent
apoptosis following exposure to tumor necrosis factor-α (TNFα)+ cycloheximide (CHX). In
contrast, Tao cells, an AhR-deficient variant of the 1c1c7 line, were refractory to this
treatment. AhR sense/antisense transfection studies demonstrated that AhR contents
influenced susceptibility to the pro-apoptotic effects of TNFα+ CHX. 1c1c7 cells and all …