[HTML][HTML] The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein

R Barouki, X Coumoul, PM Fernandez-Salguero - FEBS letters, 2007 - Elsevier
FEBS letters, 2007Elsevier
The aryl hydrocarbon (dioxin) receptor (AhR) has been studied for several decades largely
because of its critical role in xenobiotic-induced toxicity and carcinogenesis. Albeit this is a
major issue in basic and clinical research, an increasing number of investigators are turning
their efforts to try to understand the physiology of the AhR under normal cellular conditions.
This is an exciting area that covers cell proliferation and differentiation, endogenous
mechanisms of activation, gene regulation, tumor development and cell motility and …
The aryl hydrocarbon (dioxin) receptor (AhR) has been studied for several decades largely because of its critical role in xenobiotic-induced toxicity and carcinogenesis. Albeit this is a major issue in basic and clinical research, an increasing number of investigators are turning their efforts to try to understand the physiology of the AhR under normal cellular conditions. This is an exciting area that covers cell proliferation and differentiation, endogenous mechanisms of activation, gene regulation, tumor development and cell motility and migration, among others. In this review, we will attempt to summarize the studies supporting the implication of the AhR in those endogenous cellular processes.
Elsevier