[HTML][HTML] Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 protein
EV Kashuba, K Gradin, M Isaguliants, L Szekely… - Journal of Biological …, 2006 - ASBMB
EBNA-3 is one of the Epstein-Barr virus (EBV)-encoded nuclear antigens that is
indispensable for immunoblastic transformation and sustained proliferation of B-
lymphocytes. The molecular mechanisms responsible for the function of EBNA-3 are poorly
understood. We previously found that EBNA-3 interacts with an immunophilin-like protein
XAP2/ARA9/AIP, which in mammalian cells is known to interact with the latent aryl
hydrocarbon receptor (AhR). AhR is a ligand-inducible transcription factor that mediates …
indispensable for immunoblastic transformation and sustained proliferation of B-
lymphocytes. The molecular mechanisms responsible for the function of EBNA-3 are poorly
understood. We previously found that EBNA-3 interacts with an immunophilin-like protein
XAP2/ARA9/AIP, which in mammalian cells is known to interact with the latent aryl
hydrocarbon receptor (AhR). AhR is a ligand-inducible transcription factor that mediates …