[HTML][HTML] Impact of adjuvants on CD4+ T cell and B cell responses to a protein antigen vaccine: results from a phase II, randomized, multicenter trial
G Leroux-Roels, A Marchant, J Levy, P Van Damme… - Clinical …, 2016 - Elsevier
Immunogenicity and safety of different adjuvants combined with a model antigen (HBsAg)
were compared. Healthy HBV-naïve adults were randomized to receive HBs adjuvanted with
alum or Adjuvant Systems AS01B, AS01E, AS03A or AS04 at Days 0 and 30. Different
frequencies of HBs-specific CD4+ T cells 14 days post dose 2 but similar polyfunctionality
profiles were induced by the different adjuvants with frequencies significantly higher in the
AS01B and AS01E groups than in the other groups. Antibody concentrations 30 days post …
were compared. Healthy HBV-naïve adults were randomized to receive HBs adjuvanted with
alum or Adjuvant Systems AS01B, AS01E, AS03A or AS04 at Days 0 and 30. Different
frequencies of HBs-specific CD4+ T cells 14 days post dose 2 but similar polyfunctionality
profiles were induced by the different adjuvants with frequencies significantly higher in the
AS01B and AS01E groups than in the other groups. Antibody concentrations 30 days post …
