Blood platelets are anucleated circulating cells that play a critical role in hemostasis and are
also implicated in arterial thrombosis, a major cause of death worldwide. The biological
function of platelets strongly relies in their reactiveness to a variety of extracellular agonists
that regulate their adhesion to extracellular matrix at the site of vascular injury and their
ability to form rapidly growing cell aggregates. Among the membrane receptors expressed
on the cell surface, integrins are crucial for both platelet activation, adhesion and …