[HTML][HTML] Role of P-selectin, β2-integrins, and Src tyrosine kinases in mouse neutrophil–platelet adhesion

V Evangelista, S Manarini, BS Coller… - Journal of Thrombosis and …, 2003 - Elsevier
Background: The initial interaction of human polymorphonuclear leukocytes (PMN) with
activated human platelets is mediated by P-selectin and its leukocyte ligand PSGL-1;
subsequently the interaction is strengthened by activation of αMβ2 via protein tyrosine
phosphorylation mediated by Src kinases and binding of activated αMβ2 to its platelet
counterreceptor (s). Objectives: Because mouse models are being used to define the role of
PMN–platelet interactions in thrombosis and the response to vascular injury, we investigated …