The expression of CXCR4 is down-regulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia

V Rosti, M Massa, AM Vannucchi… - Blood Cells, Molecules …, 2007 - Elsevier
PURPOSE:: We studied the expression of the chemokine receptor CXCR4 on circulating
CD34+ cells of patients with myelofibrosis with myeloid metaplasia (MMM), and examined its
relationship to the severity of disease. PATIENTS AND METHODS:: Surface and intracellular
CXCR4 expression were measured flow cytometrically in 84 consecutive MMM patients, 16
patients with polycythemia vera (PV), and 20 healthy subjects. In 23 MMM patients, CXCR4
gene expression level was also quantitated by real time-RT-PCR in CD34+ cells …