[HTML][HTML] Leukocyte-platelet interaction in patients with essential thrombocythemia and polycythemia vera
A Falanga, M Marchetti, A Vignoli, D Balducci… - Experimental …, 2005 - Elsevier
OBJECTIVE: Circulating polymorphonuclear leukocyte (PMN) activation occurs in patients
with essential thrombocythemia (ET) and polycythemia vera (PV). We want to define whether
this phenomenon plays a role in the formation of circulating PMN-platelet aggregates in
these conditions. METHODS: In 80 patients (46 ET and 34 PV) and 50 control subjects, we
conducted a flow cytometric analysis to evaluate the levels of PMN-platelet aggregates
(defined as the percentage of CD11b-positive PMN coexpressing a platelet-specific marker …
with essential thrombocythemia (ET) and polycythemia vera (PV). We want to define whether
this phenomenon plays a role in the formation of circulating PMN-platelet aggregates in
these conditions. METHODS: In 80 patients (46 ET and 34 PV) and 50 control subjects, we
conducted a flow cytometric analysis to evaluate the levels of PMN-platelet aggregates
(defined as the percentage of CD11b-positive PMN coexpressing a platelet-specific marker …