Selective transduction of dendritic cells in human lymph nodes and superior induction of high-avidity melanoma-reactive cytotoxic T cells by a CD40-targeted …
BN Hangalapura, D Oosterhoff, S Aggarwal… - Journal of …, 2010 - journals.lww.com
Targeted delivery of tumor antigen genes to dendritic cells (DCs) using adenoviral (Ad)
vectors holds great potential for cancer immunotherapy. We previously showed that CD40
targeting of Ad vectors enhanced specific transduction of DC in human skin, while
simultaneously ensuring their stable maturation and superior allogeneic T-cell stimulatory
capacity. In this study, we evaluated whether CD40-targeted Ad encoding the full-length
melanoma antigen recognized by T cells-1 (CD40-Ad-MART-1) could be used to efficiently …
vectors holds great potential for cancer immunotherapy. We previously showed that CD40
targeting of Ad vectors enhanced specific transduction of DC in human skin, while
simultaneously ensuring their stable maturation and superior allogeneic T-cell stimulatory
capacity. In this study, we evaluated whether CD40-targeted Ad encoding the full-length
melanoma antigen recognized by T cells-1 (CD40-Ad-MART-1) could be used to efficiently …