Association of polymerase e–mutated and microsatellite-instable endometrial cancers with neoantigen load, number of tumor-infiltrating lymphocytes, and expression …
BE Howitt, SA Shukla, LM Sholl, LL Ritterhouse… - JAMA …, 2015 - jamanetwork.com
Importance Immune checkpoint inhibitor therapy has shown benefit in various cancers, but
their potential in endometrial cancer (EC) is unknown. Observations Prediction of
neoantigen load was performed using sequencing data from the Cancer Genome Atlas data
set. Evaluation of tumor-infiltrating lymphocytes (TILs) and PD-1 and PD-L1 expression was
performed in 63 patients with EC referred to our institution. The predicted median (range)
neoantigen load (predicted neoepitopes per sample) was proportional to the mutational …
their potential in endometrial cancer (EC) is unknown. Observations Prediction of
neoantigen load was performed using sequencing data from the Cancer Genome Atlas data
set. Evaluation of tumor-infiltrating lymphocytes (TILs) and PD-1 and PD-L1 expression was
performed in 63 patients with EC referred to our institution. The predicted median (range)
neoantigen load (predicted neoepitopes per sample) was proportional to the mutational …