Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma
AA Connor, RE Denroche, GH Jang, L Timms… - JAMA …, 2017 - jamanetwork.com
Importance Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain
poor. Advances in next-generation sequencing provide a route to therapeutic approaches,
and integrating DNA and RNA analysis with clinicopathologic data may be a crucial step
toward personalized treatment strategies for this disease. Objective To classify PDAC
according to distinct mutational processes, and explore their clinical significance. Design,
Setting, and Participants We performed a retrospective cohort study of resected PDAC, using …
poor. Advances in next-generation sequencing provide a route to therapeutic approaches,
and integrating DNA and RNA analysis with clinicopathologic data may be a crucial step
toward personalized treatment strategies for this disease. Objective To classify PDAC
according to distinct mutational processes, and explore their clinical significance. Design,
Setting, and Participants We performed a retrospective cohort study of resected PDAC, using …