[HTML][HTML] Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening
HK Baumgartner, JV Gerasimenko, C Thorne… - Journal of Biological …, 2009 - ASBMB
We have investigated in detail the role of intra-organelle Ca 2+ content during induction of
apoptosis by the oxidant menadione while changing and monitoring the Ca 2+ load of
endoplasmic reticulum (ER), mitochondria, and acidic organelles. Menadione causes
production of reactive oxygen species, induction of oxidative stress, and subsequently
apoptosis. In both pancreatic acinar and pancreatic tumor AR42J cells, menadione was
found to induce repetitive cytosolic Ca 2+ responses because of the release of Ca 2+ from …
apoptosis by the oxidant menadione while changing and monitoring the Ca 2+ load of
endoplasmic reticulum (ER), mitochondria, and acidic organelles. Menadione causes
production of reactive oxygen species, induction of oxidative stress, and subsequently
apoptosis. In both pancreatic acinar and pancreatic tumor AR42J cells, menadione was
found to induce repetitive cytosolic Ca 2+ responses because of the release of Ca 2+ from …