Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

CSD Cruz, MJ Kang - Mitochondrion, 2018 - Elsevier
Inflammation represents a comprehensive host response to external stimuli for the purpose
of eliminating the offending agent, minimizing injury to host tissues and fostering repair of
damaged tissues back to homeostatic levels. In normal physiologic context, inflammatory
response culminates with the resolution of infection and tissue damage response. However,
in a pathologic context, persistent or inappropriately regulated inflammation occurs that can
lead to chronic inflammatory diseases. Recent scientific advances have integrated the role …