[HTML][HTML] ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
EM Hammond, MJ Dorie, AJ Giaccia - Journal of Biological Chemistry, 2003 - ASBMB
The ATR kinase phosphorylates both p53 and Chk1 in response to extreme hypoxia
(oxygen concentrations of less than 0.027). In contrast to ATR, loss of ATM does not affect
the phosphorylation of these or other targets in response to hypoxia. However, hypoxia
within tumors is often transient and is inevitably followed by reoxygenation. We
hypothesized that ATR activity is induced under hypoxic conditions because of growth arrest
and ATM activity increases in response to the oxidative stress of reoxygenation. Using the …
(oxygen concentrations of less than 0.027). In contrast to ATR, loss of ATM does not affect
the phosphorylation of these or other targets in response to hypoxia. However, hypoxia
within tumors is often transient and is inevitably followed by reoxygenation. We
hypothesized that ATR activity is induced under hypoxic conditions because of growth arrest
and ATM activity increases in response to the oxidative stress of reoxygenation. Using the …