[HTML][HTML] Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress
JF Wang, X Zhang, JE Groopman - Journal of Biological Chemistry, 2004 - ASBMB
Reactive oxygen species (ROS) mediate cell damage and have been implicated in the
pathogenesis of diseases that involve endothelial injury. Cells possess antioxidant systems,
including intracellular antioxidants and ROS scavenging enzymes, that control the redox
state and prevent cell damage. In addition to intracellular antioxidants, certain growth factor
receptors can be activated under oxidative stress and trigger downstream cell survival
signaling cascades. Vascular endothelial growth factor receptor-3 (VEGFR-3) is a primary …
pathogenesis of diseases that involve endothelial injury. Cells possess antioxidant systems,
including intracellular antioxidants and ROS scavenging enzymes, that control the redox
state and prevent cell damage. In addition to intracellular antioxidants, certain growth factor
receptors can be activated under oxidative stress and trigger downstream cell survival
signaling cascades. Vascular endothelial growth factor receptor-3 (VEGFR-3) is a primary …