Amino-substituted thalidomide analogs: potent inhibitors of TNF-α production

GW Muller, R Chen, SY Huang, LG Corral… - Bioorganic & medicinal …, 1999 - Elsevier
GW Muller, R Chen, SY Huang, LG Corral, LM Wong, RT Patterson, Y Chen, G Kaplan…
Bioorganic & medicinal chemistry letters, 1999Elsevier
Thalidomide,(1), is a known inhibitor of TNF-α release in LPS stimulated human PBMC.
Herein we describe the TNF-α inhibitory activity of amino substituted analogs of thalidomide
(1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found
to be potent inhibitors of TNF-α release in LPS stimulated human PBMC.
Thalidomide, (1), is a known inhibitor of TNF-α release in LPS stimulated human PBMC. Herein we describe the TNF-α inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-α release in LPS stimulated human PBMC.
Elsevier