Why do pertussis vaccines fail?
JD Cherry - Pediatrics, 2012 - publications.aap.org
During the 2010 pertussis epidemic in California, there was considerable concern in the
press and in public health communications about the possible contribution of vaccine
failures to the problem. 1, 2 In this commentary, I examine why pertussis vaccines fail and
Table 1 lists 8 possible reasons. The first reason, and perhaps the most important one, is
that our estimates of vaccine efficacy have been inflated because of case definition. 3–11 At
the time of the pediatric diphtheria and tetanus toxoids and acellular pertussis (DTaP) …
press and in public health communications about the possible contribution of vaccine
failures to the problem. 1, 2 In this commentary, I examine why pertussis vaccines fail and
Table 1 lists 8 possible reasons. The first reason, and perhaps the most important one, is
that our estimates of vaccine efficacy have been inflated because of case definition. 3–11 At
the time of the pediatric diphtheria and tetanus toxoids and acellular pertussis (DTaP) …