Recurrent hypoglycemia can occur as a major complication of insulin replacement therapy,
limiting the long-term health benefits of intense glycemic control in type 1 and advanced type
2 diabetic patients. It impairs the normal counter-regulatory hormonal and behavioral
responses to glucose deprivation, a phenomenon known as hypoglycemia associated
autonomic failure (HAAF). The molecular mechanisms leading to defective counter-
regulation are not completely understood. We hypothesized that both neuronal (excessive …

(2RH0 vs. 2RS0) and B) at 60 min time point (2RH60 vs. 2RS60). Sorting is done for unique
genes and both signals (induced genes—shown in red and repressed genes—in blue)
included. Top 10 process networks are listed based on their—log (p-value). For list of
abbreviations see supplemental file S1 Text. doi: 10.1371/journal. pone. 0173839. g001