NLRP3 inflammasomes link inflammation and metabolic disease
D De Nardo, E Latz - Trends in immunology, 2011 - cell.com
Trends in immunology, 2011•cell.com
A strong link between inflammation and metabolism is becoming increasingly evident. A
number of recent landmark studies have implicated the activation of the NLRP3
inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of
metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review
these new developments and discuss their implications for a better understanding of
inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome …
number of recent landmark studies have implicated the activation of the NLRP3
inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of
metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review
these new developments and discuss their implications for a better understanding of
inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome …
A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.
cell.com