Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet
X Liu, Y Gao, M Li, C Geng, H Xu, Y Yang, Y Guo… - Journal of …, 2015 - Elsevier
Background & Aims Heme oxygenase 1 (HO-1)-mediated increases in adiponectin,
ameliorate the deleterious effects of obesity and metabolic syndrome; however, the effect of
HO-1 on hepatic lipid metabolism remains elusive. The aim of this study is to evaluate the
role of HO-1 in hepatic lipid metabolism. Methods Functional studies were performed using
C57BL/6J (WT) mice and Sirt1 liver specific mutant (Sirt1-deficient) mice. The molecular
mechanism was explored in primary hepatocytes and mouse liver. Results Chronic …
ameliorate the deleterious effects of obesity and metabolic syndrome; however, the effect of
HO-1 on hepatic lipid metabolism remains elusive. The aim of this study is to evaluate the
role of HO-1 in hepatic lipid metabolism. Methods Functional studies were performed using
C57BL/6J (WT) mice and Sirt1 liver specific mutant (Sirt1-deficient) mice. The molecular
mechanism was explored in primary hepatocytes and mouse liver. Results Chronic …